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American Journal of Psychiatry
High-dose Raloxifene linked to reduced risk of cognitive impairment in postmenopausal women
In the MORE study, researchers evaluated whether Raloxifene ( Evista ), a selective estrogen receptor modulator ( SERM ), affects the risk for Alzheimer’s disease.

The Multiple Outcomes of Raloxifene Evaluation ( MORE ) was a randomized,...( Read )
The New England Journal of Medicine
Mild cognitive impairment, no benefit from Donepezil after three years
Researchers of the Alzheimer's Disease Cooperative Study evaluated the effect of Vitamin E and Donepezil, an acetylcholinesterase inhibitor, in the progression from mild cognitive impairment ( MCI ) to Alzheimer’s disease.

Mild cognitiv...( Read )
Headache
Aspirin is efficacious for the treatment of acute migraine
A study, led by Richard B. Lipton at the Albert Einstein College of Medicine in New York, assessed the efficacy and tolerability of Aspirin versus placebo for the acute treatment of a single acute attack of migraine.

A total of 401 subject...( Read )
Journal of National Cancer Institute
Long-term NSAID use and breast cancer risk
Researchers, led by Sarah F. Marshall, University of Southern California, at Los Angeles, investigated the association of NSAID use with risk of breast cancer with special attention to risk of specific breast cancer subtypes and to type of NSAID use...( Read )
Cochrane Database of Systematic Reviews
Diabetes mellitus, pharmacotherapy for weight loss
Obesity is closely related to type 2 diabetes and long-term weight reduction is an important part of the care delivered to obese persons with diabetes.

Researchers of the National Center for Chronic Disease Prevention & Health Promotion, ...( Read )
Diabetes Care
Type 1 diabetes, pancreas transplant alone improves diabetic nephropathy
Successful pancreas transplant alone, through restoration of sustained normoglycemia, improves diabetic nephropathy in type 1 diabetic patients.

Researchers at the University of Pisa, Italy, evaluated whether restoration of long-lasting n...( Read )
Lancet Oncology
Gefitinib alone or in conbination with Anastrozole improves outcomes in ER- and EGFR-positive primary breast cancer
A double-blind, placebo-controlled randomised trial evaluated whether inhibition of EGFR ( Epidermal Growth Factor Receptor ) can suppress proliferation of breast cancer cells and ER ( Estrogen-Receptor ) function.

Among 56 postmenopausal ...( Read )
Archives of Internal Medicine
Blood pressure elevation is an independent risk factor of end-stage renal disease
Many cases of end-stage renal disease ( ESRD ) are ascribed to hypertension. However, because renal disease itself can raise blood pressure, some investigators argue that ESRD seen in patients with hypertension is due to underlying primary renal dise...( Read )
American Heart Journal
Higher risk of depression in patients with a new myocardial infarction and heart failure
Researchers at Rush University Medical Center compared the prevalence of depression in patients with and without heart failure ( HF ) who were hospitalized with myocardial infarction ( MI ) and also at high psychosocial risk.

Baseline dat...( Read )
The New England Journal of Medicine
Use of exhaled nitric oxide measurements for adjusting doses of inhaled corticosteroids in chronic asthma
International guidelines for the treatment of asthma recommend adjusting the dose of inhaled corticosteroids.
Measurements of the fraction of exhaled nitric oxide (FENO) constitute a noninvasive marker that may be a useful alternative for the a...( Read )
 
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